From target to patient

At each level of study, we focus on the identification, investigation and validation of the potential of novel compounds by determining the relationship between the pharmacodynamic effect and the compound concentration.

The efficacy of a molecule depends on its mechanism of action, formulation, route and schedule of administration, pharmacokinetic profile and toxicity. Therefore, the compound’s efficacy, when administered to a patient, results from its interactions with the pathological or healthy environment.

The systems which are presented below are connected to each other and able us to understand the limits of efficacy of a new compound, from a simple physiological environment to a more complex one.

The connections between those levels allow us to go through more and more complex systems, to better predict the activity of novel molecules in human and to decrease the risks during the clinical phases which are the most expensive.

To improve those connections we use imaging tools (MRI and PET) that act as translational tools that enable us to bridge the gap between tumor bearing rodents and patients.