Nanocyclix® Medicinal Chemistry
Nanocyclix® is Oncodesign's proprietary medicinal chemistry technology that is used in its Drug and Biomarker Discovery Programs. The application of the technology in a diversity based chemocentric platform approach has allowed Oncodesign to identify attractive lead compounds that are pursued in a series of internal programs. In addition, the broad know-how obtained on the synthesis and optimization of this type of macrocyclic small molecules allows Oncodesign to propose the application of the technology on partner compounds that require further optimization.
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Nanokinib® is
a kinase
focused library of proprietary small molecule macrocycles that Oncodesign
has created using its Nanocyclix®
technology. The current library contains over 4,000 diverse kinase
inhibitors that were broadly profiled across the human kinome and in
early ADME (eADME) models. The compounds typically display low
nanomolar potencies against a small number of kinases. Inhibitor leads
have been discovered both for established and unexplored kinases. Each
compound of the Nanokinib® library was
individually designed to display good cell penetration and attractive
physicochemical properties.
More info
on Nanokinib®
Nanocyclix® is Oncodesign's proprietary medicinal chemistry technology ...
READ MORE
Nanokinib® is a kinase focused library of proprietary small molecule macrocycles that Oncodesign has created using its Nanocyclix® technology.
READ MORE