Restricted and controlled access to the laboratory
Availability of main reference drugs
Laminar air flow hood equipped with 3 HEPA H14 filters and an anti-vibration surface
(marble top) dedicated to the precise weighing of powders under protected atmosphere: protection of products, handlers and environment
Semi-micro balance with an accuracy of 0.01mg under 41g and 0.1mg under 120g
Dedicated refrigerator, freezer and safety cupboards of products
Experiments performed by the laboratory
Pre-clinical formulation of test substances before administration to rodents:
suspension/solution of known and unknown products
Preparation of test substances supplied by sponsor following SOP
Stability studies of compounds in vehicle for administration
Storage and management of tested compounds
Aim of these experiments in drug development
To enhance drug bioavailability and absorption by the development of new solutions/suspensions compatible with administration to rodents involved in tolerance and antitumor activity studies
To compare the activity of new formulations with actual galenic forms
To guarantee the reproducibility of drug preparation for administration to rodents
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