[Webinar] How to better optimize an oncology drug discovery program
Register for this webinar discussing how conventional and innovative integrated technological skills should be incorporated into an oncology program.Read more
Since the integration of Nanocyclix® into Oncodesign in 2010, we have significantly expanded the technology to a platform containing over 11,000 inhibitors based on over 50 different scaffolds and over 300 different linkers. These molecules have been extensively characterized against the human kinome and in ADME tests. As a pioneering company in precision medicine and artificial intelligence, Oncodesign has leveraged our vast Nanocyclix® knowledge base to increase the efficiency and speed of development of new therapeutic and diagnostic products. Nanocyclix® enjoys strong industry recognition with multiple past and present drug discovery partnerships: Ipsen, Sanofi, UCB, Guerbet, Cyclopharma, Bristol-Myers Squibb and Servier.
|Collection of > 11 000 Macrocyclic Kinase Inhibitors||Nanocyclix prime properties|
|> 50 scaffolds , > 300 linkers||Attractive molecular properties with consistent SAR|
|Potent and selective type 1 inhibitors with low MW||Cellular potency as an intrinsic property|
|Annotated across the human kinome and in ADME||Potential to cross BBB|
|Different shape based paradigm - unique value proposition||Addressing unexplored and intractable kinases|
|Not a screening library : these are all kinase inhibitors||Prone to radio-labelling for diagnostics design|
|Next generation kinase inhibitors in cancer|
The molecular weight of a Nanocyclix® kinase inhibitor, even after complete optimization, is generally around 350 to 450 daltons, significantly lower than a linear inhibitor with similar potency and selectivity. This generates a more drug-like profile that is still optimized using a rational and structure-based design and multi-parameter optimization (MPO) techniques from modern medicinal chemistry.
Nanocyclix® molecules can precisely target untreatable and unexplored kinases in various kinase families, including lipid kinases. Due to their small size and limited conformation space, the Nanocyclix® inhibitors easily cross cell membranes and even cross the blood-brain barrier. They can also be radiolabeled with 18F for diagnostic purposes. Kinome selectivity