ANTICANCER ACTIVITY OF MYCOBACTERIAL CELL WALL-DNA COMPLEX (MCC) IN A MODEL OF RAT COLON CANCER PERITONEAL CARCINOMATOSIS

Authors: Mario C. FILION, Caroline MIGNARD, Olivier RAGUIN, Benoit FILION, Francis BICHAT and Nigel C. PHILLIPS
Bioniche Life Sciences Inc., Oncodesign Biotechnology

Abstract: Mycobacterial cell wall-DNA complex (MCC) is a bifunctional anticancer agent that induces apoptosis in
cancer cells and stimulates immune effector cells. The objective of this study was to evaluate the potential
use of MCC as a localized treatment for peritoneal carcinomatosis. The antiproliferative activity of MCC
towards rat DHD/K12/TRb colon cancer cells (PROb) in vitro, the in vivo recruitment of immune cells in the
peritoneal cavity following repeated IP administrations of MCC and the in vivo antitumor activity of MCC
against disseminated PROb colon cancer tumors in the peritoneal cavity of syngeneic BDIX rats were
evaluated.

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