[Webinar] How to better optimize an oncology drug discovery program
Register for this webinar discussing how conventional and innovative integrated technological skills should be incorporated into an oncology program.Read more
Authors: F Bichat, D France, O Duchamp, P Auvray, B Hill, M Vincenti, N Gyselinck, P Genne
Oncodesign; Centre de Recherche Pierre Fabre; Laboratoires Pierre Fabre Oncologie
Abstract: Vinflunine (VFL) is a novel fluorinated vinca-alkaloid derivative which has shown antitumor activity in experimental Nude mouse models. In order to develop an assay to test VFL in combination with other chemotherapeutic agents, we have studied the antitumor activity and the tolerance to VFL administered as 4 weekly IV injections (q7dx4) to Nude rats bearing subcutaneous (SC) NCI-H69 human lung tumors.