[Webinar] How to better optimize an oncology drug discovery program
Register for this webinar discussing how conventional and innovative integrated technological skills should be incorporated into an oncology program.
Read more Authors: Celma C, Peraire C, Obach R, Bichat F, Guilbaud N, Genne P, Principe P
Ipsen Pharma; Oncodesign; Beaufour Ipsen
Homocamptothecins (HCPTs) are novel anticancer drugs issued from research at Beaufour Ipsen, HCPTs inhibit topoisomerase I (Topo I): in contrast with camptothecins they possess a 7-membered-beta-hydroxylactone ring that displays reduced electrophilicity leading to a considerable stabilization of the active, closed lactone form of the drug…