ANTITUMOUR, PHARMACOKINETICS AND DISTRIBUTION STUDIES OF DIFLOMOTECAN (BN80915) ADMINISTERED INTRAVENOUSLY TO NUDE RATS XENOGRAFTED WITH HUMAN NSC NCI-H460 LUNG TUMOUR CELLS

Authors: Celma C, Peraire C, Obach R, Bichat F, Guilbaud N, Genne P, Principe P
Ipsen Pharma; Oncodesign; Beaufour Ipsen

Homocamptothecins (HCPTs) are novel anticancer drugs issued from research at Beaufour Ipsen, HCPTs inhibit topoisomerase I (Topo I): in contrast with camptothecins they possess a 7-membered-beta-hydroxylactone ring that displays reduced electrophilicity leading to a considerable stabilization of the active, closed lactone form of the drug…

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