Oncodesign, Covalab, CheMatech and ABX-CRO launch DRIVE™-MRT
A premium complete, integrated service offer for radiopharmaceuticals drug discovery and generation
Authors: Celma C, Peraire C, Obach R, Bichat F, Guilbaud N, Genne P, Principe P
Ipsen Pharma; Oncodesign; Beaufour Ipsen
Homocamptothecins (HCPTs) are novel anticancer drugs issued from research at Beaufour Ipsen, HCPTs inhibit topoisomerase I (Topo I): in contrast with camptothecins they possess a 7-membered-beta-hydroxylactone ring that displays reduced electrophilicity leading to a considerable stabilization of the active, closed lactone form of the drug…