Discovery of Novel Inhibitors of PIM-1 Kinase Enabled by Generative AI


Rohit Arora, Anna Kriukova, Maud Jusot, Nicolas Devaux, Brice Hoffmann, Christopher Housseman, Quentin Perron
Yann Lamotte, Pascaline Jacquemard, Quentin Janet, Anthony Martinez, Stéphane Sautet, Alexis Denis


  • Use generative AI to generate and identify new PIM-1 kinase inhibitor hits with activity <1 μM, freedom-to-operate (FTO), and good in vitro ADME properties.
  • Use this as a case-study to demonstrate the benefits and capabilities of the generative AI technology developed at Iktos.

Read the poster here