Discovery of Novel Inhibitors of PIM-1 Kinase Enabled by Generative AI

Authors:

Rohit Arora, Anna Kriukova, Maud Jusot, Nicolas Devaux, Brice Hoffmann, Christopher Housseman, Quentin Perron
Yann Lamotte, Pascaline Jacquemard, Quentin Janet, Anthony Martinez, Stéphane Sautet, Alexis Denis

Objectives:

  • Use generative AI to generate and identify new PIM-1 kinase inhibitor hits with activity <1 μM, freedom-to-operate (FTO), and good in vitro ADME properties.
  • Use this as a case-study to demonstrate the benefits and capabilities of the generative AI technology developed at Iktos.

Read the poster here

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