Parkinson’s disease: Servier and Oncodesign announce the selection of a preclinical candidate
Initiated in March 2019, this Research and Development partnership is focused on the identification of LRRK2 kinase inhibitors derived from Oncodesign’s proprietary Nanocyclix® platform and their potential to act as therapeutic agents against Parkinson’s disease, drawing on Servier and Oncodesign’s complementary expertise in the field of neurodegenerative disease and kinase inhibitors.
Strategic collaboration to provide the pharmaceutical industry with a unique and integrated solution for the discovery and development of radiopharmaceutical products from the target through to the clinical phase
Full continuum of innovative technologies with access to the partners’ expertise for a unique theranostic Drug Discovery process
Dijon (France), June 28, 2021 at 06:00pm CEST – ONCODESIGN (FR0011766229 – ALONC), a biopharmaceutical group specialized in precision medicine, today announces a strategic collaboration agreement with Covalab, a specialist in the development and production of bespoke antibodies with a unique nanobody library, CheMatech, European leader in the design, synthesis and supply of chelating agents, and ABX-CRO, specialized in the preclinical and clinical development of radiopharmaceuticals in oncology.
The combination of these fields of expertise has led to the launch of the DRIVE-MRT™ (Molecular RadioTherapy) offer incorporating the entire Drug Discovery process specialized in targeted systemic radiotherapy (Theranostics) from the generation of radio-labeled biological vectors, the optimization of leads and the generation of preclinical drug candidates through to the granting of IND and the designing and running of radiopharmaceutical clinical studies.
The DRIVE-MRT solution allows the rationalization, design and optimizationof targeted radiopharmaceutical products that are effective against certain metastatic cancers.
Since Lutathera, indicated for the treatment of inoperable or metastatic somatostatin receptor-positive gastroenteropancreatic neuroendocrine tumors (GEP-NET), until the recent results reported to ASCO this year regarding the substantial increase in survival observed for 177Lu-labeled PSMA-ligand vectorized internal radiation therapy in patients with metastatic high-grade castrate-resistant prostate cancer (CRPC), targeted vectorized radiotherapy is now attracting numerous players in the pharmaceutical industry as well as clinicians seeking effective treatments for metastatic diseases. According to a recent study, the global vectorized radiotherapeutic product market should see growth of approximately 40% between 2019 and 2025, reaching an estimated $8.0 billion in 2025.
Philippe Genne, Chairman and CEO and founder of Oncodesign, says: “Within the framework of our drug discovery service market development approach and like our first DRIVE-SM offer, specific of small chemical molecules, we are showing ourselves to be a champion at this precise moment on this emerging new market segment where we can rely on over a decade of experience in radiopharmaceuticals acquired notably with radiotracers and PharmImage. We are pleased to be joining forces with these top-tier partners in order to provide this new service offer, a driver of the discovery of drugs for translational research, from preclinical to clinical, to help the radiopharmaceutical sector’s many clients. Historically, Oncodesign has supplied innovative drug discovery programs on behalf of third-party clients – this partnership marks a new chapter for our DRIVE offer and for the radiopharmaceutical industry”.
Fabrice Viviani, General Manager and Head of the Oncodesign Service Business Unit, adds: “We are delighted to be joining forces with Covalab, CheMatech and ABX-CRO, major recognized players in the discovery and design of new innovative drugs for precision medicine. It is by combining our strengths and fields of expertise that we are now able to provide the unique and fully integrated DRIVE-MRT offer covering the discovery of the target, the generation of radiopharmaceutical vectors and their clinical development in oncology”.
 Rapport MEDraysintell 2019 – Nuclear medicine market report
Oncodesign is a biopharmaceutical company dedicated to precision medicine, founded in 1995 by its current CEO and majority shareholder, and has been listed on Euronext Growth Market since April 2014. Its mission is the discovery of effective therapies to fight cancer and other diseases without therapeutic solutions. With its unique experience acquired by working with more than 800 clients, including the world’s largest pharmaceutical companies, along with its unique technological platform combining Artificial Intelligence, state-of-the-art medicinal chemistry, pharmacology, regulated bioanalysis, medical imaging, Oncodesign is able to select new therapeutic targets, design and develop potential preclinical candidates through to clinical phases. Oncodesign has configured its organization to offer innovative services to its customers and to license its proprietary molecules. Applied to kinase inhibitors, which represent a market estimated at over $65 billion by 2027 and accounting for almost 25% of the pharmaceutical industry’s R&D expenditure, Oncodesign’s technology has already enabled the targeting of several promising molecules with substantial therapeutic potential, in oncology and elsewhere, along with partnerships with global pharmaceutical groups. Oncodesign is based in Dijon, France, in the heart of the town’s university and hospital hub, and within the Paris-Saclay cluster. Oncodesign has 233 employees within 3 Business Units (BU): Service, Biotech, Artificial Intelligence and subsidiaries in Canada and the USA.
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