Parkinson’s disease: Servier and Oncodesign announce the selection of a preclinical candidate
Initiated in March 2019, this Research and Development partnership is focused on the identification of LRRK2 kinase inhibitors derived from Oncodesign’s proprietary Nanocyclix® platform and their potential to act as therapeutic agents against Parkinson’s disease, drawing on Servier and Oncodesign’s complementary expertise in the field of neurodegenerative disease and kinase inhibitors.
Akanksha Gangar, PhD, Study Director 28 Avril 2020 17h00 – 17h45 – CEST
Immunological cell death (ICD) is a form of cancer cell death induced by radiotherapy, photodynamic therapy and chemotherapeutic agents. Unlike apoptosis or necrosis, ICD can induce an effective immune response directed against the tumor whereby both dendritic cells and T lymphocytes are mediators of this response. Dying cancer cells recruit and activate immune cells by releasing damage-associated molecular patterns (DAMPs).
Using our in-house developed screening strategy facilitated by an in vitro platform with four assays, we have identified and characterized several ICD inducers and a Nanocyclix compound for the three key DAMPs and cell viability in several cell lines. Evaluation of phagocytosis and cytokine levels showed that ICD activates both innate and adaptive arms of the immune system. With respect to cancer immunotherapy, the ICD process elicits enhanced adjuvanticity and antigenicity from dying cancer cells and consequently, promotes the development of clinically desired antitumor immunity.
In essence, we describe a novel strategy for the identification of ICD inducers within large chemical libraries followed by ex-vivo co-culture assays to demonstrate enhanced DC and T cell function.
Key learning objectives
Introduction to ICD
How Oncodesign can help you to identify / characterize ICD inducers in vitro, ex vivo and in vivo
About our speaker Akanksha Gangar
Akanksha Gangar obtained her PhD in Biochemistry from the prestigious Indian Institute of Science. She then continued as a postdoctoral research associate at the University of North Carolina at Chapel Hill to study cell polarity. In 2005, Akanksha joined INSERM, France as a Research Scientist to work on cell polarity in an oncological context. She joined GSK, France in 2007 to support their drug development in hypertension, diabetes, obesity and oncology. In 2016, Akanksha joined Oncodesign’s in vitro department as a Study director focusing on cancer related projects.
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