Animal models for novel therapies on fibrosis and NASH

Authors:

Adélaïde Ferment, Jeremy Odillard, Ingrid Jacquet, Benedicte Devin, Laure Levenez, Gaël Krysa, Robin Artus,
Franck Martin, Edwige Nicodeme, Olivier Duchamp, Fabrice Viviani and Samira Benhamouche-Trouillet

Abstract:

We have used a model of NASH-HCC with number of cellular and molecular processes that are reflective of
human NASH and outcomes. Our objectives were to assess:

  • the effect of Elafibranor (Ela) or/and Obeticholic Acid (OCA) on the development of NASH and fibrosis.
  • the effect of Lenvatinib or/and anti-PD-1 on the development of hepatocellular carcinomas (HCC).
  • to assess the sex differences on the pathogenesis and the response to treatments.

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