SOLO – PoC Inflammation

SOLO-PoC Inflammation: Proof-of-concept pharmacology in inflammatory diseases

SOLO-PoC Inflammation is part of our translational pharmacology platform in immunology with a large selection of in vitro and preclinical in vivo models of inflammation and autoimmune diseases

Inflammation and preclinical models2
  • Support for your research projects and products to assess novel targets and the efficacy of new therapeutic approaches and innovative mechanisms of action for anti-inflammatory pharmacological effects
  • Various preclinical models ranging from immune modulation, restoration, suppression and stimulation up to specific models of injury induced by acute or chronic inflammation in multiple organs:
    • skin inflammation in dermatology: psoriasis, atopic dermatitis, scleroderma, pruritus
    • intestinal inflammation: ulcerative colitis, irritable bowel
    • liver inflammation: chemo-induced acute injuries, models of fibrosis and chronic inflammation, NASH
    • lung inflammation: idiopathic pulmonary fibrosis, bronchiolitis
    • central inflammation: multiple sclerosis
    • kidney inflammation: chemo-induced acute injury
    • type 1 or type 2 diabetes
  • Specialized support and expert advice in the definition and design of preclinical studies for target validation, investigation of mechanisms of action, in vitro and in vivo pharmacodynamics and in vivo anti-inflammatory efficacy
Study design-inflammation
  • Relevant analyses and readouts to assess the pharmacological activity of your products, covering:
    • clinical scoring analyses
    • assessment of effects at modulating of cytokine profile
    • effects on immune populations analyzed flow cytometry
    • histological analyses of inflamed tissues