Ressources Scientifiques
Posters
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28/03/2022
Scientific Posters | AACR 2022
Find all 4 posters that are presented during AACR 2022. They unveil our expertise in oncology using our scientific know-how (medicinal chemistry, radio-imaging, in vivo model and microbiome)
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27/09/2021
Structure-Based Design of small macrocyclic CDK9 degraders as chemical biology tools and beyond
With small macrocyclic “probes” from our proprietary library in the low nanomolar range IC50, we turned our attention to CDK9 inhibitors with good selectivity profile against CDK1/2/5/7 as a starting point for building bifunctional small macrocyclic kinase degraders.
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26/08/2021
Discovery of Novel Inhibitors of PIM-1 Kinase Enabled by Generative AI
Use generative AI to generate and identify new PIM-1 kinase inhibitor hits with activity, freedom-to-operate, and good in vitro ADME properties.
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20/04/2021
Pharmacokinetic and Biodistribution of Formatted Affimer® Biotherapeutics Targeting PD-L1
Programmed Cell Death-Ligand 1 (PD-L1) is part of the immune checkpoint system involved in preventing autoimmunity. PD-L1 is upregulated on tumors cells and binds to its receptor, PD-1, expressed by immune cells in the tumor microenvironment.
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14/04/2021
Tumor-specific molecular changes in luminal B breast cancer patient-derived xenografts (PDXs) with acquired resistance to endocrine treatment
In this study we describe establishment of a luminal breast cancer PDX model with acquired resistance to hormonotherapy